When the immune system’s ability to fight infectious diseases  is compromised or entirely absent. Most cases are acquired, some are born with the condition. An immunocompromised animal can be vulnerable to opportunistic infections in addition to normal infections that can affect an animal with a normally working immune system. free resources
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A person standing still 300 yards away is almost invisible to a dog

But a dog can easily identify its owner standing a mile away if the owner is waving his/her arms